S7 Airway Pathological Phenotypes and their Clinical Utility in Adult Asthma
نویسندگان
چکیده
منابع مشابه
Clinical phenotypes of asthma.
PURPOSE OF REVIEW Asthma is a phenotypically heterogeneous disorder and, over the years, many different clinical subtypes of asthma have been described. A precise definition of asthma phenotypes is now becoming more and more important, not only for a better understanding of pathophysiologic mechanisms, but in particular to ascertain the specific genes associated with these phenotypes. RECENT ...
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OBJECTIVE To characterize clinical phenotypes of severe asthma. METHODS A total of 111 patients were retrospectively evaluated at a specialized outpatient clinic. A systematic protocol for patient evaluation and follow-up was applied. Treatment compliance and control of the disease at the end of follow-up were defined by clinical and functional data. Patients who did not meet asthma control c...
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Asthma is a heterogeneous disease that means not all asthmatics respond to the same treatment. We hypothesize an approach to characterize asthma phenotypes based on symptomatology (shortness of breath (SOB), cough, and wheezy phenotypes) in correlation with airway inflammatory biomarkers and FEV1. We aimed to detect whether those clinical phenotypes have an impact on the response to asthma medi...
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RATIONALE Heterogeneity in asthma expression is multidimensional, including variability in clinical, physiologic, and pathologic parameters. Classification requires consideration of these disparate domains in a unified model. OBJECTIVES To explore the application of a multivariate mathematical technique, k-means cluster analysis, for identifying distinct phenotypic groups. METHODS We perfor...
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BACKGROUND The lower airways harbor a community of bacterial species which is altered in asthma. OBJECTIVES We examined whether the lower airway microbiota were related to measures of asthma severity. METHODS We prospectively recruited 26 severe asthma, 18 non-severe asthma and 12 healthy subjects. DNA was extracted from induced sputum and PCR amplification of the V3-V5 region of bacterial ...
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ژورنال
عنوان ژورنال: Thorax
سال: 2015
ISSN: 0040-6376,1468-3296
DOI: 10.1136/thoraxjnl-2015-207770.13